British Air Force Typhoon jets have operated alongside French aircraft in a joint strike targeting an underground arms cache in Syrian territory employed by the IS group, according to the UK's MoD.
The facility, identified by surveillance, was assessed as containing munitions and bombs, the announcement noted, and was positioned in hills just above the ancient city of Palmyra in the heart of Syria.
"The RAF jets used laser-guided Paveway IV weapons to hit a several entry passages providing entry to the depot... early reports suggest the target was engaged successfully," the MoD said.
There was no sign of any civilian casualties in the strike conducted Saturday night and all the aircraft returned safely, the MoD added.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - enforced militant control over large swathes of both Syria and Iraq until 2019.
"This strike underscores British leadership, and resolve to stand shoulder to shoulder with our partners, to stamp out any revival of Daesh and their dangerous and violent ideologies in the area," UK Defence Secretary John Healey said.
British military aircraft have conducted surveillance missions over Syria to "prevent any attempted resurgence" of the group subsequent to its military defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank every member of the UK armed forces participating in this mission for their expertise and their valour," he added. "They were among thousands of UK service members deployed over the holidays. This operation, to take out militants who threaten our safety, highlights how our armed forces are always on standby, continuously, protecting the UK at home and powerful internationally."
Last December, the United States armed forces carried out what it described as a "massive strike" targeting Daesh sites in the country, subsequent to an assault claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The U.N. says Islamic State still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.